ABSTRACT
OBJECTIVE: To study the coumarins from Mallotus conspurcatus. METHODS: The ethyl acetate part of 75% ethanol extracts from Mallotus conspurcatus was isolated. The compounds were isolated and purified with column chromatography, and their structures were elucidated on the basis of 1H-NMR, 13C-NMR and ESI-MS data. RESULTS: Twelve coumarins were determined to be malloapelin A (1), 5'-demethyl aquillochin (2), aquillochin (3), cleomiscosin B (4), 6-hydroxy-7-methoxy-coumarin (5), braylin (6), aegelinol (7), bergapten (8), isofraxidin (9), fraxidin (10), grevillone (11), and fraxetin (12). CONCLUSION: Compounds 6-12 are isolated from this genus for the first time.
ABSTRACT
Objective: To investigate the chemical constituents of Mallotus conspurcatus. Methods: The ethyl acetate part of 75% ethanol extracts from M. conspurcatus was separated through chromatographic techniques. The isolates were identified on the basis of 1H-NMR, 13C-NMR, and ESI-MS data. Results: Eighteen known compounds were isolated. They were 1,5-dihydroxy-3-methoxy-7- methyl-anthraquinon (1), (-)-syringaresinol (2), 2,3-dihydro-5,7-dihydroxy-2,8-dimethyl-6-(3-methyl-2-butenyl)-4H-1-benzo-4-one (3), 2,3-dihydro-5,7-dihydroxy-2,6,8-tri-methyl-4H-1-benzopyran-4-one (4), paeoveitol B (5), pinellic acid (6), trans-p- hydroxycinnamic acid (7), trans-p-methoxycinnamic acid (8), trans-p-hydroxy-ethyl cinnamate (9), p-hydroxybenzoic acid (10), 3-methoxy-4-hydroxybenzoic acid (11), 3,4-dihydroxybenzoic acid (12), ferulic acid (13), syringic acid (14), syringic acid ethyl ester (15), hexadecanoic acid 2,3-dihydroxy-propyl ester (16), galic acid (17), and ethyl gallate (18). Conclusion: Besides compounds 3, 4, and 13, the other compounds are isolated from the plants of Mallotus Lour. for the first time.
ABSTRACT
The genus Mallotus Lour. (Euphorbiaceae) consists of 140 species distributed in tropical and subtropical regines of Asia, 25 species and 11 varieties of which can be found in southern of China. Some species of the genus have been used in traditional medicine. Phytochemical studies on the plants in the genus have demonstrated the presence of large number of diterpenoids, triterpenoids, polyphenols, and tannins, along with some monoterpene, benzopyran, coumarin-lignin, diaryl heptane, flavonoids, alkaloids, coumarin, etc. Furthermore, many pharmacological activities of the plants in the genus, such as anti-atherosclerosis, choleretic, hepatoprotective, antioxidant, analgesic, immunity improvement, and memory enhancing activities have been reported. In this article, new development of constituents and biological activities of plants in Mallotus Lour. since 1988 were reviewed and summarized for providing a reference for the further study, exploitation, and utilization of this resource.